Wednesday, July 25, 2007
Tuesday, June 19, 2007
Monday, June 18, 2007
Take a look and and post a comment.
(I am sure that you will have time to read half page article and say something about the topic though you are intensively doing research)
Tuesday, June 12, 2007
Tuesday, May 08, 2007
Wednesday, April 25, 2007
PS: I'm glad that the 06/07 class has started joining this blog! I hope more people will write here! Cheers, Ana.
Thursday, April 12, 2007
Wednesday, April 04, 2007
As far as I've read, the prizes are presented by genuine Nobel Laureates, originally at a ceremony in a lecture hall at MIT, but now in Harvard University. The ceremony is followed a few days later by the Ig Informal Lectures at the MIT, in which laureates have the opportunity to explain their achievements and their relevance to the general public.
See the list of past winners here! It's so funny!
How has someone thought in calculating the number of photographs one must take to (almost) ensure that nobody in a group photo will have their eyes closed? And what about the study that tries to determine why, when you bend dry spaghetti, it often breaks into more than two pieces? :) These were the 2006 Maths and Physics' winners, respectively!
Tuesday, March 27, 2007
Once it was thought to be proportional to the size of the genome. Then, we found that most of the genome of some organisms was apparently doing nothing since it did not code any proteins, so it was postulated that organismal complexity was proportional to the number of genes. Thus, it came as shock that we humans, of all organisms, had a relatively modest number of genes with respect to our intuitive notion of complexity.
Nowadays people talk of the regulatory interactions between genes as the true key to organismal complexity. According to this view, intricate regulation and not sheer number of proteins should reflect the complexity of an organism.
A relatively new player in this mind-game is miRNA. Strong evidence suggests that microRNAs are effectors of an intricate, fine-tuned regulatory network that acts combinatorially on mRNA transcripts. And, according to some estimates, more than half of the coding genes of vertebrates have their expression modulated by microRNAs.
An excellent introduction to this topic can be found here.
Commonly used lab bacteria called E. coli can be converted into light-harvesting organisms in a single genetic step, according to new research from MIT. The genetic enhancement allows microorganisms that normally derive their cellular energy from sugars to switch to a diet of sunlight. These findings could ultimately be used to genetically engineer bacteria that can more efficiently produce biofuels, drugs, and other chemicals.
Wednesday, March 14, 2007
This high-resolution, three-dimensional image of a eukaryotic cell was created by researchers led by Claude Antony of the European Molecular Biology Laboratory in Heidelberg, Germany. They scanned 250-nanometre-thick slices of frozen fission yeast and assembled the scans into a computer-generated 3D image.
So, I was curious, and I tried to find what diseases are charaterized this way. And why! I'm writing this post because I thought this could be a great topic of discussion.
There are 13 tropical diseases considered to be 'neglected', because not enough money is spent on researching and/or distributing cures (e.g., leprosy). I've read that the 13 all have some fundamental traits in common, not in terms of their biology, namely:
But, do you know what I also found interesting? The open-source 'Tropical Disease initiative' also refers to Orphan Diseases (illnesses on which phamaceutical companies tend to do little research)! They argue that there is an overlap between 'neglected' and 'orphan' diseases, but the latter group includes TB and malaria.
Ancient afflictions that have burdened humanity for centuries Poverty-promoting conditions Associated with stigma Rural areas of low-income countries and fragile states No commercial markets for products that target these diseases Interventions, when applied, have a history of success
By the way, do you know that some people argue that malaria is not a tropical disease? World largest outbreaks of malaria in recent time occured in siberia and norway in the 19th Century!
Wednesday, February 21, 2007
Friday, February 09, 2007
Wednesday, January 31, 2007
And if you don't believe the man, take a look at these "pérolas":
Tuesday, January 23, 2007
It is my second post (first non-latin) here, so I thought I should (re-)start with something light.
After some weeks worrying about bureaucracy, trips to IKEA and calling the Utilities companies asking for a monthly bill (rather than an annual or semi-annual one which is, so it seems, the default procedure in France) I finally started working on my PhD project.
It is snowing in Lyon, which is something I wished to share with all of you - it's pretty! (I would take a picture myself but it is already too dark for that - the photo on this post is from last year).
I've been reading some exciting new articles on miRNA which I will post here as soon as I have read them all (it may take some time - be warned) but yesterday I came across an interesting piece of news here and I would like to hear your thoughts on the matter.
And I should also give you the link to my latest paper (comments are more than welcomed).
Sunday, January 21, 2007
I found inevitable to post about this paper. Though I know that for some of you this will not change a thing in the research project, the paper reports a big change for the ones o work more close with metabolism.
The representation of chemical compounds has been a big issue for Chemists and Biologists. Biologists in particular have found an increasing difficulty dealing with the amount of metabolites as metabolic networks grow in complexity (see link).
In order to explain this issue I will give you a small example. Go to KEGG database and do a search for glucose. This does not seem strange because glucose can assume different forms and so different names, but just take a careful look in the second hit. Well, I know that grapes are sweet but not so sweet to have their own sugar. I am sure that this funny example does not represent a problem for Biochemists but imagine if you find in your database a compound with so many names that you decide to check this compound in other database like, let us say BioCyc. Ups... Now I am confused. What is really the name of the compound? Is this the same compound that I was looking for? Well, better days will come before I finish my accurate metabolic network with 500 metabolites.
Taking some of these problems in account, IUPAC launched in 2001 a project to develop a nomenclature for representing the chemical structure of organic molecules in a unique digital string. A test version of the International Chemical Identifier (InChI) was released in March 2002 and three years later the first version of the InChI software was released. In August 2006 an update version was released along with a validation protocol to check the validity of the output and we can start finding this nomenclature in numerous databases as NIH/NCI, NIH/PubChem, Thomsom/ISI and MDL/Elsevier, as well as search compounds with this nomenclature in Google.
This nomenclature is still in his infancy and let us see what changes it will bring in Chemistry and in Biology.
P.S. - Thanks for the tip Mr. Correia :P
Saturday, January 20, 2007
Many of you may know already, but is never to much to remind it:
Intelligent Systems in Molecular Biology and European Conference in Computational Biology 2007. It's going to be in Austria in July, it looks like a very good conference to attend and besides that could be a good meeting point...
Saturday, January 13, 2007
Friday, January 05, 2007
Enjoy and maybe the question does even make sense.
Me, Myself and My Ego
PS. - The title was actually a link, so now it is here: http://www.simulation-argument.com/simulation.html